Oestrogen influences the immune system and typically suppresses inflammatory processes in the body. When oestrogen levels drop during menopause, the immune system can become more active. Other physical changes may also contribute to this.
These hormonal changes can reveal a hidden autoimmune disease or worsen an existing one. In autoimmune diseases, the immune system attacks parts of the body itself. For example, healthy cells that support organ function may be destroyed. In other cases, inflammation can occur as unnecessary cells are cleared away. A drop in oestrogen can lead to increased immune system activity. If you have a hidden or existing autoimmune disease, it may suddenly manifest or worsen.
Some women discover during menopause that they have an autoimmune disease, such as rheumatoid arthritis, lupus, or Hashimoto's thyroiditis. Symptoms may also become more severe, which can be mentally challenging.