Angeliq is a hormone replacement therapy designed to relieve menopausal symptoms. It contains two hormones: estradiol (bio-identical, resembling the natural female hormone) and drospirenone (a synthetic hormone). This combination can help with symptoms such as hot flushes, night sweats, vaginal dryness, and mood swings, which are common during menopause.
Angeliq

In short
- For symptoms such as hot flushes, poor sleep, vaginal dryness
- May help with mood swings, fatigue, irritability
- Tablet containing bio-identical and synthetic hormones
- Prescription-only medication
What is Angeliq?
What can you expect from Angeliq?
- Angeliq replenishes the deficiency of female hormones during menopause.
- It is a tablet taken daily.
- You may notice an improvement in your symptoms within a few weeks.
When should I use Angeliq?
- Take one tablet daily, at the same time each day.
- Continue taking the tablet without interruption, even during menstruation.
- Do not use if you are pregnant or breastfeeding.
The package leaflet contains all the information about this product. Read the leaflet before using the product.
For which symptoms is Angeliq used?
- Hot flushes/night sweats
- Vaginal dryness
- Mood swings
Angeliq may also help with:
- Sleep problems
- Fatigue
- Irritability
Do not use Angeliq if you:
- Are allergic to estradiol, drospirenone, or other ingredients.
- Are pregnant or breastfeeding.
- Have an increased risk of blood clots, active thrombosis, or a history of thrombosis.
- Have a severe liver condition or a tumour sensitive to oestrogens.
- Have certain heart or kidney problems (see the leaflet for details).
Consult the prescribing doctor if you are taking other medications. Angeliq may interact with other drugs.
Possible side effects of Angeliq
Common (in 1 to 10 out of 100 people):
Headache
Abdominal pain
Tender or painful breasts
Irregular bleeding
Vaginal discharge
Mood changes
Uncommon (in 1 to 10 out of 1,000 people):
High blood pressure
Weight gain
Muscle cramps
Nausea
Back pain
Rare (in fewer than 1 out of 1,000 people):
Blood clots
Liver problems
Allergic reactions
These side effects can, in rare cases, lead to serious conditions such as blood clots or liver problems. Always contact a doctor immediately in such cases.
For a complete list of side effects, read the package leaflet.
Risks of hormone replacement therapy
If you still have a uterus, oestrogen must be combined with progesterone/progestogen, as using oestrogen alone increases the risk of uterine cancer.
The use of medication carries risks, and this also applies to menopausal hormone therapy. For tablets or capsules containing oestrogen and progesterone/progestogen, the following risks apply:
A slightly increased risk of thrombosis, strokes, and gallbladder problems.
Rarely, but an increased risk of breast cancer. This risk appears to increase the longer you use the medication (over 5 years).
Recent studies indicate that menopausal hormone therapy (when started before the age of 60) can have protective effects in addition to its risks. This includes protection against certain types of cancer, osteoporosis, and diabetes.
Scientific sources
Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions - PubMed
Cognitive health after menopause: Does menopausal hormone therapy affect it? - PubMed
Impact of estrogens on resting energy expenditure: A systematic review - PubMed
Cognition and mental health in menopause: A review - PubMed
The role of estrogen in female skeletal muscle aging: A systematic review - PubMed
Oestrogen-based therapies for menopausal symptoms - PubMed
2016 IMS Recommendations on women's midlife health and menopause hormone therapy - PubMed
Management of unscheduled bleeding on hormone replacement therapy (HRT) - British Menopause Society
Rethinking Menopausal Hormone Therapy: For Whom, What, When, and How Long? - PubMed
Hormone Therapy in Menopause: Concepts, Controversies, and Approach to Treatment - PubMed
Updates in Hormone Replacement Therapy for Survivors of Gynecologic Cancers - PMC
Oestrogen-based therapies for menopausal symptoms - PubMed
The 2022 hormone therapy position statement of The North American Menopause Society - PubMed
Hormone Therapy in Menopause - PubMed
Hormoonsuppletietherapie en het risico op veneuze trombo-embolie | Stichting Geneesmiddelenbulletin
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Patient Information Leaflet
Read the patient information leaflet carefully before using Angeliq.
Angeliq helps with
Frequently asked questions
Will my treatment be covered?
This depends on your health insurance provider. We recommend you check with your own insurance company. Supplements are not usually covered.
What is a consultation and how does it work?
During the consultation, you will complete a comprehensive medical questionnaire. You can also state your preferred type of treatment. Based on your answers, a doctor will prepare a treatment plan for you within 48 hours. If you approve this plan, a pharmacy will dispatch the products to your home within 3 days.
How long will it take to receive my order?
Our partner pharmacies will dispatch your order within 3 days. You can then typically start your treatment straight away.
Are there delivery charges?
For prescription medicines, delivery is included in the price. For over-the-counter products, there is a delivery charge of £4.21. We offer free delivery on orders over £40. If your order includes both, delivery is free.
Can I change, cancel or return my order?
Unfortunately, once an order has been placed, it cannot be changed. If you have ordered the wrong product, or wish to change or cancel your order, please contact our customer service team immediately. Over-the-counter products can only be cancelled if they have not yet been prepared or dispatched by the pharmacy. Prescription medicines can be cancelled if they have not yet been assessed by a doctor. Returns are only accepted for over-the-counter products in their original unopened and undamaged packaging, within 14 days of dispatch.