Senshio is a medication designed to assist postmenopausal women experiencing symptoms such as vaginal dryness, irritation, and pain during intercourse, which are caused by a lack of oestrogen during menopause. The medication contains ospemifene, a selective oestrogen receptor modulator (SERM). This is a non-hormonal treatment that works in a tissue-specific manner on oestrogen receptors and can improve the condition of the vaginal wall. Senshio is prescribed when local treatments, such as vaginal creams or tablets, are not suitable.
Senshio




In short
- For vaginal dryness, irritation, and pain during intercourse
- May help with itching or burning sensations
- Tablet containing ospemifene (SERM, non-hormonal)
- For postmenopausal women with moderate to severe vaginal symptoms
- Prescription medication
What is Senshio?
What can you expect from Senshio?
Senshio supports the health of the vaginal wall and may help reduce dryness, irritation, and pain during intercourse. It is a prescription-only medication in tablet form. A noticeable effect is typically observed after a few weeks of use, with optimal results achieved after approximately 12 weeks. Results and the speed of improvement may vary from person to person.
When should I use Senshio?
- Senshio is taken daily in tablet form.
- It is important to take Senshio at the same time each day.
- This medication is intended for postmenopausal women with moderate to severe vaginal symptoms when local treatments are not suitable.
- Be mindful of potential interactions if you are taking other medications. In such cases, consult the doctor who prescribed this medication.
The package leaflet contains all the information about this product. Ensure you read the leaflet before using the product.
For which symptoms is Senshio used?
Primarily helps with:
- Vaginal dryness
- Pain during intercourse (dyspareunia)
- Vaginal irritation or itching after menopause
May also help with:
- A burning sensation in and around the vagina
- An unpleasant or tight feeling in the vaginal wall
Do not use Senshio if you:
- Are allergic to ospemifene or any of the excipients
- Are pregnant or breastfeeding
- Have or have had an oestrogen-dependent tumour (such as certain types of breast cancer or skin cancer)
- Have unexplained vaginal bleeding
- Have or have had a blood clot, such as deep vein thrombosis or pulmonary embolism
- Have severe liver problems
- Are taking medications that affect the action of Senshio, such as fluconazole, ketoconazole, rifampicin, or bosentan
If you are unsure whether you can combine Senshio with other medications, consult the doctor who prescribed it.
Possible side effects of Senshio
Common (in 1 to 10 out of 100 people):
- Hot flushes
- Vaginal discharge
- Muscle cramps
Uncommon (in 1 to 10 out of 1,000 people):
- Vaginal yeast infection
- Thickening of the uterine lining (endometrial thickening)
- Blood clots, such as deep vein thrombosis or pulmonary embolism
Rare (in fewer than 1 out of 1,000 people):
- Severe allergic reaction
- Liver problems
In rare cases, these side effects can lead to serious conditions, such as blood clots in the legs or lungs. In such situations, always contact a doctor immediately.
For a complete list of side effects, refer to the package leaflet.
Scientific sources
- Pharmacokinetics, pharmacodynamics and clinical efficacy of ospemifene for the treatment of dyspareunia and genitourinary syndrome of menopause: Expert Opinion on Drug Metabolism & Toxicology: Vol 12 , No 10 - Get Access
- Nonestrogen Therapies for Treatment of Genitourinary Syndrome of Menopause
- Overall Safety of Ospemifene in Postmenopausal Women from Placebo-Controlled Phase 2 and 3 Trials | Journal of Women's Health
- Ospemifene for the treatment of vulvar and vaginal atrophy: A meta-analysis of randomized trials. Part I: Evaluation of efficacy - Maturitas
- Ospemifene for the treatment of vulvar and vaginal atrophy: A meta-analysis of randomized trials. Part II: Evaluation of tolerability and safety - Maturitas
Medically reviewed by

Patient Information Leaflet
Read the patient information leaflet carefully before using Senshio.
Senshio helps with
Frequently asked questions
Will my treatment be covered?
This depends on your health insurance provider. We recommend you check with your own insurance company. Supplements are not usually covered.
What is a consultation and how does it work?
During the consultation, you will complete a comprehensive medical questionnaire. You can also state your preferred type of treatment. Based on your answers, a doctor will prepare a treatment plan for you within 48 hours. If you approve this plan, a pharmacy will dispatch the products to your home within 3 days.
How long will it take to receive my order?
Our partner pharmacies will dispatch your order within 3 days. You can then typically start your treatment straight away.
Are there delivery charges?
For prescription medicines, delivery is included in the price. For over-the-counter products, there is a delivery charge of £4.21. We offer free delivery on orders over £40. If your order includes both, delivery is free.
Can I change, cancel or return my order?
Unfortunately, once an order has been placed, it cannot be changed. If you have ordered the wrong product, or wish to change or cancel your order, please contact our customer service team immediately. Over-the-counter products can only be cancelled if they have not yet been prepared or dispatched by the pharmacy. Prescription medicines can be cancelled if they have not yet been assessed by a doctor. Returns are only accepted for over-the-counter products in their original unopened and undamaged packaging, within 14 days of dispatch.