Trisequens is a hormone replacement therapy that may help alleviate menopausal symptoms such as hot flushes, poor sleep, vaginal dryness, and mood swings. Trisequens contains two types of hormones in varying compositions: bioidentical estradiol (similar to the natural oestrogen in your body) and synthetic norethisterone (a form of progesterone). This combination replenishes the deficiency of female hormones and helps reduce menopausal symptoms. Trisequens is specifically designed for women with a uterus. This medication is available by prescription only.
Hormone replacement therapy
Trisequens
Tablet
In short
- For symptoms such as hot flushes, poor sleep, and vaginal dryness.
- May help with mood swings, night sweats, and forgetfulness.
- Tablet containing bioidentical and synthetic hormones
- Designed for women with a uterus experiencing menopausal symptoms
- Prescription-only medication
What is Trisequens?
What can you expect from Trisequens?
- Hormone replacement therapy in tablet form
- Works by replenishing female hormones
- You may notice an improvement in symptoms within a few days to weeks
- When using Trisequens, you may experience a monthly withdrawal bleed.
When should I use Trisequens?
- Take one tablet daily as per your doctor’s instructions
- Take the tablets at the same time each day.
- Note: Only use if you have a uterus.
- Not suitable if you are pregnant or breastfeeding.
The package leaflet contains all the information about this product. Read the leaflet before using the product.
For which symptoms is Trisequens used?
- Hot flushes
- Poor sleep
- Vaginal dryness
Trisequens may also help with:
- Mood swings
- Fatigue
- Irritability
Do not use Trisequens if you:
- Are allergic to estradiol, norethisterone, or other ingredients
- Have or have had blood clots (such as thrombosis or pulmonary embolism)
- Have or have had liver disease
- Have or have had breast cancer or another hormone-sensitive cancer
- Have unexplained vaginal bleeding
- Have severe heart or vascular diseases
Inform your prescribing doctor if you are taking other medications. This medication may interact with other drugs.
Possible side effects of Trisequens
Common (affecting 1 to 10 in 100 people):
Headache
Abdominal pain
Nausea
Tender breasts
Breakthrough bleeding or spotting (light bleeding between periods)
Uncommon (affecting 1 to 10 in 1,000 people):
Mood changes
Weight gain
Fluid retention
Migraine
Back pain
Rare (affecting fewer than 1 in 1,000 people):
Skin rash
Gallbladder disorders
Increased risk of blood clots
In rare cases, these side effects can lead to serious conditions, such as blood clots. Always contact a doctor immediately in such cases.
For a complete list of side effects, refer to the package leaflet.
Risks of hormone replacement therapy
If you still have a uterus, oestrogen must be combined with progesterone/progestogen, as using oestrogen alone increases the risk of uterine cancer.
The use of medication carries risks, and this also applies to menopausal hormone therapy. For tablets or capsules containing oestrogen and progesterone/progestogen, the following risks apply:
A slightly increased risk of thrombosis, strokes, and gallbladder problems.
Rarely, an increased risk of breast cancer. This risk appears to rise the longer the medication is used (more than 5 years).
Recent studies indicate that menopausal hormone therapy (when started before the age of 60) can offer protective effects in addition to its risks. These include protection against certain types of cancer, osteoporosis, and diabetes.
Scientific sources
Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions - PubMed
Cognitive health after menopause: Does menopausal hormone therapy affect it? - PubMed
Impact of estrogens on resting energy expenditure: A systematic review - PubMed
Cognition and mental health in menopause: A review - PubMed
The role of estrogen in female skeletal muscle aging: A systematic review - PubMed
Oestrogen-based therapies for menopausal symptoms - PubMed
Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions - PubMed
Cognitive health after menopause: Does menopausal hormone therapy affect it? - PubMed
Impact of estrogens on resting energy expenditure: A systematic review - PubMed
Cognition and mental health in menopause: A review - PubMed
The role of estrogen in female skeletal muscle aging: A systematic review - PubMed
Oestrogen-based therapies for menopausal symptoms - PubMed
2016 IMS Recommendations on women's midlife health and menopause hormone therapy - PubMed
Management of unscheduled bleeding on hormone replacement therapy (HRT) - British Menopause Society
Rethinking Menopausal Hormone Therapy: For Whom, What, When, and How Long? - PubMed
Hormone Therapy in Menopause: Concepts, Controversies, and Approach to Treatment - PubMed
Updates in Hormone Replacement Therapy for Survivors of Gynecologic Cancers - PMC
Oestrogen-based therapies for menopausal symptoms - PubMed
The 2022 hormone therapy position statement of The North American Menopause Society - PubMed
Hormone Therapy in Menopause - PubMed
Hormoonsuppletietherapie en het risico op veneuze trombo-embolie | Stichting Geneesmiddelenbulletin
Medically reviewed by
Dr. Erik KnauffRegistration number:: 89059736001
Patient Information Leaflet
Read the patient information leaflet carefully before using Trisequens.
Trisequens helps with
Frequently asked questions
Will my treatment be covered?
This depends on your health insurance provider. We recommend you check with your own insurance company. Supplements are not usually covered.
What is a consultation and how does it work?
During the consultation, you will complete a comprehensive medical questionnaire. You can also state your preferred type of treatment. Based on your answers, a doctor will prepare a treatment plan for you within 48 hours. If you approve this plan, a pharmacy will dispatch the products to your home within 3 days.
How long will it take to receive my order?
Our partner pharmacies will dispatch your order within 3 days. You can then typically start your treatment straight away.
Are there delivery charges?
For prescription medicines, delivery is included in the price. For over-the-counter products, there is a delivery charge of £4.21. We offer free delivery on orders over £40. If your order includes both, delivery is free.
Can I change, cancel or return my order?
Unfortunately, once an order has been placed, it cannot be changed. If you have ordered the wrong product, or wish to change or cancel your order, please contact our customer service team immediately. Over-the-counter products can only be cancelled if they have not yet been prepared or dispatched by the pharmacy. Prescription medicines can be cancelled if they have not yet been assessed by a doctor. Returns are only accepted for over-the-counter products in their original unopened and undamaged packaging, within 14 days of dispatch.