Hormone replacement therapy

Utrogestan

Capsule

In short

Protects against, among other things, heavy bleeding during oestrogen supplementation
May help improve poor sleep
Capsule containing bioidentical hormone progesterone
For women with a uterus undergoing oestrogen supplementation
Prescription-only medication

What is Utrogestan?

Utrogestan is a medication containing the hormone progesterone. This is a bioidentical hormone, which is also naturally present in the body. The capsules are used as part of hormone replacement therapy for menopausal symptoms. Utrogestan is typically prescribed as a supplement to oestrogen hormone replacement therapy for women with a uterus. It complements the effects of oestrogen, protects the uterine lining from excessive growth, and reduces the risk of uterine cancer. It may also assist with poor sleep. Utrogestan is available by prescription only.

What can you expect from Utrogestan?

Utrogestan is a hormone replacement therapy in capsule form. It supplements the progesterone deficiency that can occur during menopause and oestrogen supplementation. Most people notice a reduction in symptoms within a few weeks, though the effect can vary from person to person. Utrogestan only works when used in combination with oestrogen therapy. It protects the uterine lining from excessive growth caused by oestrogen.

When should I use Utrogestan?

Use Utrogestan daily as directed by your doctor, usually in combination with oestrogen supplementation.
Take the capsules orally, following your doctor’s advice.

The package leaflet contains all the information about this product. Please read the leaflet before using the product.

For which symptoms is Utrogestan used?

This medication is specifically used to prevent heavy menstrual bleeding and to maintain a healthy uterine lining during oestrogen supplementation.

It may also help with:

Poor sleep

Do not use Utrogestan if you:

Are allergic to progesterone or any of the other ingredients
Are pregnant or breastfeeding
Have severe liver conditions
Have (or have had) blood clots or thrombosis
Have unexplained vaginal bleeding
Have certain types of cancer (such as breast cancer or uterine cancer)
Are taking certain other medications that are incompatible with Utrogestan (refer to the leaflet for a complete list)
Are unsure about combining it with other medications; consult your doctor
Do not have a uterus, unless specifically prescribed by your doctor

Possible side effects of Utrogestan

Common (affecting 1 to 10 out of 100 people):

Drowsiness
Dizziness
Headache
Tender breasts
Irregular menstruation
Abdominal pain

Uncommon (affecting 1 to 10 out of 1,000 people):

Nausea
Diarrhoea
Fatigue
Mood changes
Skin reactions

Rare (affecting fewer than 1 out of 1,000 people):

Allergic reactions
Jaundice
Blood clots

In rare cases, these side effects can lead to serious symptoms, such as difficulty breathing, facial swelling, jaundice (yellowing of the skin or eyes), or signs of thrombosis (sudden pain, swelling, or redness in a leg, chest pain, shortness of breath). Always contact a doctor immediately if you experience these symptoms.

Most women experience few or mild side effects. The package leaflet contains a complete list of possible side effects.

Risks of hormone replacement therapy

The use of medication can carry risks, and this is also true for menopausal hormone replacement therapy. Progesterone/progestogen is prescribed as a supplement to oestrogen treatment if you still have a uterus, as otherwise there is an increased risk of uterine cancer. Are you using a product containing oestrogen and still have a uterus? Check the potential risks of using progesterone/progestogen in combination with oestrogen on the specific product page.

Scientific sources

Efficacy of Micronized Progesterone for Sleep: A Systematic Review and Meta-analysis of Randomized Controlled Trial Data - PubMed

Effects of progestogens used in menopause hormone therapy on the normal breast and benign breast disease in postmenopausal women - PubMed

Menopausal hormone therapy and women's health: An umbrella review - PubMed

Different regimens of menopausal hormone therapy for improving sleep quality: a systematic review and meta-analysis - PubMed

Review of menopausal hormone therapy with estradiol and progesterone versus other estrogens and progestins - PubMed

Management of Menopausal Symptoms: A Review - PubMed

Hormone therapy for sexual function in perimenopausal and postmenopausal women - PubMed

Progestogens for endometrial protection in combined menopausal hormone therapy: A systematic review - PubMed

Risks and benefits of hormone therapy after menopause for cognitive decline and dementia: A conceptual review - PubMed

Metabolism of progestogens used for contraception and menopausal hormone therapy - PubMed

Neuroendocrine mechanisms of mood disorders during menopause transition: A narrative review and future perspectives - PubMed

Progestogens in Menopausal Hormone Therapy: A Double-Edged Sword - PubMed

2016 IMS Recommendations on women's midlife health and menopause hormone therapy - PubMed

Menopausal symptoms and treatment-related effects of estrogen and progestin in the Women's Health Initiative - PubMed

Management of unscheduled bleeding on hormone replacement therapy (HRT) - British Menopause Society

Menopausal hormone therapy and incidence, mortality, and survival of breast cancer subtypes: a prospective cohort study - PubMed

Rethinking Menopausal Hormone Therapy: For Whom, What, When, and How Long? - PubMed

Hormone Therapy in Menopause: Concepts, Controversies, and Approach to Treatment - PubMed

FSRH Guideline Contraception for Women Aged Over 40 Years / fsrh-guideline-contraception-for-women-aged-over-40-years.pdf / PDF4PRO

Updates in Hormone Replacement Therapy for Survivors of Gynecologic Cancers - PMC

Oestrogen-based therapies for menopausal symptoms - PubMed

The 2022 hormone therapy position statement of The North American Menopause Society - PubMed

Hormone Therapy in Menopause - PubMed

Effect of oral and transdermal estrogen replacement therapy on hemostatic variables associated with venous thrombosis: a randomized, placebo-controlled study in postmenopausal women - PubMed

Vaginal administration of estradiol: effects of dose, preparation and timing on plasma estradiol levels - PubMed

Ultra-low dose estradiol and dydrogesterone for the treatment of menopausal symptoms in a pooled, multi-ethnic population - PubMed

Changes in menopause-specific quality of life between women with transdermal estradiol versus oral estrogens: results of a randomized controlled trial - PubMed

Hormoonsuppletietherapie en het risico op veneuze trombo-embolie | Stichting Geneesmiddelenbulletin

Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases - PubMed

Effects of estradiol administration on brain activation and anhedonia in perimenopausal women: A pharmaco-fMRI study - PubMed

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Prices
Dosage & pack size	Price
Utrogestan 100mg 30 caps.	£31.00
Utrogestan 100mg 60 caps.	£44.00

Utrogestan helps with

Urinary incontinence

Urinary tract infection (UTI)

Vaginal thrush

Vaginal dryness

Hot flushes

Difficulty concentrating and brain fog

Discover how it works

A personal treatment plan for your symptoms

80% of women in menopause experience symptoms. Fortunately, you can do something about them. Start your consultation and receive a personal treatment plan from a doctor.

Man in a white medical coat typing on a laptop at a desk by a window with a blurred outdoor view in soft daylight

1
Complete a medical questionnaire
At your own pace, you complete the comprehensive medical questionnaire to outline your situation and treatment preferences. Following this, you finalise the ID check and pay 43 pounds for the treatment plan.
2
Get a treatment plan
Within 48 hours, the doctor will develop a personalised treatment plan for the first three months, tailored to your symptoms, medical condition, and treatment preferences. You then decide which products you wish to order and complete the payment.
Any questions? Just ask the doctor in the chat. We will save your recommendation for 30 days, giving you plenty of time to think it over.
3
Start your treatment
Within three days, you will receive the products from the pharmacy at home, along with a complimentary nutrition and lifestyle guide filled with tips from our hormone therapist. This way, you can promptly begin your treatment. During the treatment, the doctor will follow up with you, and you can also ask questions via the chat.

Frequently asked questions about Utrogestan

How quickly does Utrogestan work?

When should you take Utrogestan?

What does Utrogestan do?

Frequently asked questions

Will my treatment be covered?

What is a consultation and how does it work?

How long will it take to receive my order?

Are there delivery charges?

Can I change, cancel or return my order?

Unfortunately, once an order has been placed, it cannot be changed. If you have ordered the wrong product, or wish to change or cancel your order, please contact our customer service team immediately. Over-the-counter products can only be cancelled if they have not yet been prepared or dispatched by the pharmacy. Prescription medicines can be cancelled if they have not yet been assessed by a doctor. Returns are only accepted for over-the-counter products in their original unopened and undamaged packaging, within 14 days of dispatch.