Zoely is a combination pill primarily prescribed as a contraceptive. This tablet can also provide relief from menopausal symptoms when used as hormone replacement therapy. It is intended for women who still have a uterus and/or still (occasionally) menstruate (perimenopause). The tablet contains two active ingredients: bioidentical estradiol and nomegestrol, a synthetic hormone that mimics the effects of progesterone. These hormones help stabilise hormone levels, which may reduce menopausal symptoms. This medication is available only by prescription.
Hormone replacement therapy
Zoely
Tablet
In short
- For symptoms such as hot flushes, poor sleep, and vaginal dryness.
- May help with mood swings, night sweats, and forgetfulness.
- Tablet containing bioidentical and synthetic hormones.
- For women with menstruation and/or contraceptive needs.
- Prescription medication.
What is Zoely?
What can you expect from Zoely?
Zoely is a tablet taken daily. It works by supplementing and stabilising the levels of female hormones in your body. This can help reduce menopausal symptoms such as hot flushes, night sweats, and poor sleep. The effects and results vary from person to person, but many women notice a reduction in symptoms after a few weeks. It is often prescribed as a contraceptive. The combination of active ingredients suppresses ovulation and makes the cervical mucus more difficult for sperm to penetrate.
When should I use Zoely?
- Take it daily, following the schedule on the packaging. A so-called "break week" is not necessary.
- Take the tablets at the same time each day.
The package leaflet contains all the information about this product. Read the leaflet before using the product.
For which symptoms is Zoely used?
- Hot flushes/night sweats
- Heart palpitations
- Painful muscles and joints
- Poor sleep and fatigue
- Concentration problems
- Vaginal symptoms such as dryness or recurrent yeast infections
Zoely may also help with:
- Mental symptoms such as mood swings and irritability
- Skin issues such as dry skin and skin ageing
- Changes in body odour
- Loss of muscle mass and strength
- Gastrointestinal symptoms
- Dry and itchy eyes
- Frequent urination
Do not use Zoely if you:
- Are allergic to any of the ingredients.
- Are pregnant or breastfeeding.
- Have an increased risk of blood clots, cardiovascular disease, or stroke.
- Have a severe liver condition.
- Have certain types of cancer, such as breast cancer or uterine cancer.
- Experience unexplained vaginal bleeding.
Inform your doctor if you are taking other medications, as Zoely may interact with them. The package leaflet contains all the information about this product, including potential interactions.
Possible side effects of Zoely
Common (in 1 to 10 out of 100 users):
Headache
Abdominal pain
Nausea
Tender or sore breasts
Irregular bleeding
Uncommon (in 1 to 10 out of 1,000 users):
Mood swings
Weight gain
Fatigue
Rare (in fewer than 1 out of 1,000 users):
Blood clots in the legs or lungs
Severe allergic reactions
In rare cases, these side effects can lead to serious symptoms, such as chest pain, shortness of breath, sudden difficulty breathing, severe headache, or swelling in one leg. Always contact a doctor immediately in these situations.
Risks of hormone replacement therapy
If you still have a uterus, oestrogen must be combined with progesterone/progestogen, as using oestrogen alone increases the risk of uterine cancer.
The use of medication can involve risks, and this is also true for menopausal hormone replacement therapy. For tablets or capsules containing oestrogen and progesterone/progestogen, the following risks are associated:
A slightly increased risk of thrombosis, strokes, and gallbladder problems.
Rarely, but an increased risk of breast cancer. This risk appears to grow the longer the medication is used (over 5 years).
Recent studies indicate that menopausal hormone replacement therapy (when started before the age of 60) may also offer protective benefits in addition to risks. These include protection against certain types of cancer, osteoporosis, and diabetes.
Risks of hormone replacement therapy
If you still have a uterus, oestrogen must be combined with progesterone/progestogen, as using oestrogen alone increases the risk of uterine cancer.
The use of medication carries risks, and this also applies to menopausal hormone replacement therapy. For tablets or capsules containing oestrogen and progesterone/progestogen, the following risks apply:
A slightly increased risk of thrombosis, strokes, and gallbladder problems.
Rarely, but an increased risk of breast cancer. This risk appears to increase the longer you use the medication (over 5 years).
Recent studies indicate that menopausal hormone replacement therapy (when started before the age of 60) can have protective effects in addition to its risks. This includes protection against certain types of cancer, osteoporosis, and diabetes.
Scientific sources
Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions - PubMed
Cognitive health after menopause: Does menopausal hormone therapy affect it? - PubMed
Impact of estrogens on resting energy expenditure: A systematic review - PubMed
Cognition and mental health in menopause: A review - PubMed
The role of estrogen in female skeletal muscle aging: A systematic review - PubMed
Oestrogen-based therapies for menopausal symptoms - PubMed
2016 IMS Recommendations on women's midlife health and menopause hormone therapy - PubMed
Management of unscheduled bleeding on hormone replacement therapy (HRT) - British Menopause Society
Rethinking Menopausal Hormone Therapy: For Whom, What, When, and How Long? - PubMed
Hormone Therapy in Menopause: Concepts, Controversies, and Approach to Treatment - PubMed
Updates in Hormone Replacement Therapy for Survivors of Gynecologic Cancers - PMC
Oestrogen-based therapies for menopausal symptoms - PubMed
The 2022 hormone therapy position statement of The North American Menopause Society - PubMed
Hormone Therapy in Menopause - PubMed
Hormoonsuppletietherapie en het risico op veneuze trombo-embolie | Stichting Geneesmiddelenbulletin
2016 IMS Recommendations on women's midlife health and menopause hormone therapy - PubMed
Management of unscheduled bleeding on hormone replacement therapy (HRT) - British Menopause Society
Rethinking Menopausal Hormone Therapy: For Whom, What, When, and How Long? - PubMed
Hormone Therapy in Menopause: Concepts, Controversies, and Approach to Treatment - PubMed
Updates in Hormone Replacement Therapy for Survivors of Gynecologic Cancers - PMC
Oestrogen-based therapies for menopausal symptoms - PubMed
The 2022 hormone therapy position statement of The North American Menopause Society - PubMed
Hormone Therapy in Menopause - PubMed
Hormoonsuppletietherapie en het risico op veneuze trombo-embolie | Stichting Geneesmiddelenbulletin
Medically reviewed by
Dr. Erik KnauffRegistration number:: 89059736001
Zoely helps with
Frequently asked questions
Will my treatment be covered?
This depends on your health insurance provider. We recommend you check with your own insurance company. Supplements are not usually covered.
What is a consultation and how does it work?
During the consultation, you will complete a comprehensive medical questionnaire. You can also state your preferred type of treatment. Based on your answers, a doctor will prepare a treatment plan for you within 48 hours. If you approve this plan, a pharmacy will dispatch the products to your home within 3 days.
How long will it take to receive my order?
Our partner pharmacies will dispatch your order within 3 days. You can then typically start your treatment straight away.
Are there delivery charges?
For prescription medicines, delivery is included in the price. For over-the-counter products, there is a delivery charge of £4.21. We offer free delivery on orders over £40. If your order includes both, delivery is free.
Can I change, cancel or return my order?
Unfortunately, once an order has been placed, it cannot be changed. If you have ordered the wrong product, or wish to change or cancel your order, please contact our customer service team immediately. Over-the-counter products can only be cancelled if they have not yet been prepared or dispatched by the pharmacy. Prescription medicines can be cancelled if they have not yet been assessed by a doctor. Returns are only accepted for over-the-counter products in their original unopened and undamaged packaging, within 14 days of dispatch.