You can think of the liver as a waste treatment plant, an organ that detoxifies toxic substances that we take in. The liver plays a key role in cholesterol metabolism, breaking down fats and proteins, and purifying the blood. It also breaks down and removes any excess hormones from the body, preventing imbalances.
So, a healthy liver is crucial for hormonal balance. In perimenopause your hormone levels change, which is why good liver function is so important during this transition time. What can you do to support your liver?
Every day, the liver detoxifies the body of substances such as alcohol, coffee, medication and chemicals in our food and other products. When the liver has too much to handle it can get overworked, affecting its ability to work optimally.
Women expose themselves to hundreds of chemicals every day. The liver has to process all these chemicals.
What's more, all these detoxifying processes need to happen before the liver can focus on metabolising and removing used hormones from the body. If hormones are not broken down efficiently, this does not have life-threatening consequences. However, if toxins (such as alcohol and medication) are not eliminated, they can damage vital organs, potentially causing death. Therefore, the liver prioritises getting toxins out of the bloodstream over hormones. If the liver is too busy metabolising toxins to eliminate hormones, this can lead to hormonal imbalances.
Research shows that the drop in oestrogen levels brought on by menopause increases the risk of a fatty, malfunctioning liver. Postmenopausal women, in particular, are prone to a fatty liver. Factors such as stress and insulin resistance can increase this risk.
These are important factors that can prevent the liver from breaking down hormones. Oestrogens are eliminated from the body by metabolic conversion to metabolites. If metabolites remain in the body too long, this can cause problems. Metabolites are endocrine disruptors that interfere with normal hormonal action, so you don't want them in your body.
Nutrition and liver health – and thus overall health and a healthy hormone balance – are deeply interconnected. Are you looking for ways to support the health of your liver and ensure that it functions optimally? Then make sure your diet includes certain nutrients (like organic vegetables, water and protein) and certain restrictions (like alcohol and sugary, processed and deep-fried foods). Confused what to include, and what not to include in your diet? Here are some tips.
During perimenopause you need to be kind to your liver. This doesn’t mean you have to detox. A healthy diet, rest and relaxation, and cutting down or quitting alcohol is enough to support your liver as you go through menopause.
Brady CW. (2025). Liver disease in menopause. World J Gastroenterol. PMID: 26167064.
Mezey E. Liver disease and protein needs. PMID: 6764731.
WebMD, (2022). Nutrition to Help Your Liver. https://www.webmd.com/hepatitis/ss/slideshow-foods-help-liver