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Weight gain

Weight gain and menopause: what you need to know

I keep putting on weight. My wardrobe is stuffed with clothes in different sizes. - Maria (age 54)

Many middle-aged women notice changes in their body shape and overall weight. Although weight gain around menopause serves a purpose, it can be detrimental to body image. What causes this rapid weight gain? What role do hormones play, and what can you do to stop packing on pounds?

What is happening in your body?

The female body goes through major changes as it transitions to menopause and beyond. The ovaries gradually start producing less of the female sex hormones oestrogen and progesterone. However, in the years leading up to the menopause, progesterone levels drop faster than oestrogen levels, causing an oestrogen dominance effect. The higher your oestrogen levels, the more fat is stored in your body.  

Reduced levels of oestrogen can cause fat to be stored around your waist rather than on your hips and thighs. As a result, you may notice that your belly is getting bigger. This serves a purpose: belly fat plays an important role in reducing menopausal symptoms. This is because belly fat cells generate their own local production of oestrogen. So, your growing tummy is actually a sign that your body is taking care of you.  

As oestrogen levels drop further in subsequent years, you lose muscle mass. This slows down your metabolism because your muscles don’t use as much energy as before. This means that if you don’t change your eating habits, you are likely to gain weight. 

Hormonal changes can also trigger a variety of menopausal symptoms, such as hot flashes, sleep problems and mood swings. 

Products that help with weight gain

Belly fat is the body’s backup system for when a woman’s ovaries stop the production of female sex hormones. Belly fat cells generate their own local production of oestrogen, which benefits your skin.

Insulin resistance and reduced leptin levels

In many women, weight gain is not only related to menopausal hormone fluctuations. Often there are several imbalances at play, which may or may not be caused by the same hormones. For instance, hormonal fluctuations can cause the body to respond less well to insulin, the hormone that absorbs sugar from food and converts it into energy. This can cause you to gain weight suddenly or keep you from losing weight successfully. 

Reduced oestrogen levels can also affect how leptin works in the body. Leptin is a hormone that sends a signal to your brain when you are satiated or hungry. It’s a natural appetite suppressant. So, less oestrogen means less leptin, which means you feel hungry more often. If you feel hungry more often, you’re more likely to eat bigger servings or reach for snacks (which can develop into a habit of late-night snacking or binging). 

Weight loss medication: Product comparison

There are different types of weight loss medication. This product comparison clearly shows you the differences. Choose your preferred treatment, fill in the medical questionnaire and you will receive a medical consultation and prescription within 48 hours. The pharmacy will deliver your order within 3 working days.

Product comparison Wegovy Orlistat (Xenical) Mysimba Xenical Alli capsules (orlistat)
Dosage form
Injector pen Capsule Extended-release tablet Capsule Capsule
Active ingredient
Semaglutide Orlistat Naltrexone/bupropion Orlistat Orlistat
Effect
GLP1 agonist Prevents the action of enzymes found in the digestive juices which break down fats Reduces the feeling of hunger Prevents the action of enzymes found in the digestive juices which break down fats Prevents the action of enzymes found in the digestive juices which break down fats
Result
Weight loss due to decreased food intake Active ingredient prevents the breakdown of fats in food Weight loss Active ingredient prevents the breakdown of fats in food Active ingredient prevents the breakdown of fats in food
Possible weight loss impact
> 20% 5-10% if combined with a low-calorie diet 5-10% 5-10% if combined with a low-calorie diet 50% more weightloss with reduced-calorie, low-fat diet
Onset of action
Takes effect within a few hours. Effect lasts approximately one week. Takes effect after 1.5 hours Approx. three hours Takes effect after 1.5 hours Takes effect after 1.5 hours
Use/frequency
Weekly according to dosing schedule Maximum use: 3 x per day Daily according to schedule Maximum use: 3 x per day Maximum use: 3 x per day
Go to product Go to product Go to product Go to product Go to product

Other causes

Reduced levels of progesterone can also cause the thyroid to become underactive. One of the most important functions of the thyroid is regulating metabolism, the body’s internal combustion engine. If you already have an underactive thyroid, your symptoms can become more severe.  

Fluctuating hormone levels have also been linked to mood and happiness. If you don’t feel good about yourself, you’re more likely to reach for snacks that give you a serotonin boost. Serotonin is the happiness hormone and improves mood. The same applies to poor sleep: if you wake up feeling exhausted, you’re much more likely to reach for carbs for a quick energy fix.  

Last but not least, hormonal fluctuations can also make you more sensitive to stress. When you are under a lot of stress, your body enters fight-or-flight mode (causing it to produce more of the stress hormone cortisol which breaks down tissue), rather than resting and digesting (which promotes tissue buildup and the production of sex hormones). This can affect blood glucose levels, which in turn can lead to sugar cravings. 

The body is one big system that is meant to work together in a balanced way.

Hormone replacement therapy for menopausal symptoms

Weight gain during the menopausal transition

It’s clear that there are many factors that affect weight. At perimenopause, which is marked by low progesterone and an oestrogen dominance, many women notice a slight increase in weight. The further along in the menopausal transition, the more your body changes. Research has shown that approximately 60 to 70 percent of women gain weight during their menopausal years, on average one to two pounds per year between the ages of 50 and 60.

With the right tools, losing weight in your menopausal years is far from impossible. Be kind to yourself and set realistic goals.

It's never too late to lose weight

It's absolutely possible for menopausal women who have gained weight to get back to their original body size. But it will take some effort. Discover what supplements and medical treatments can help you to reach a healthy weight.

What can you do?

Even if your eating habits remain the same, you can gain weight at midlife. Understanding what is happening in your body, taking care of yourself and making some minor adjustments will put you in control of your weight (and alleviate discomfort and menopausal symptoms). 

  • Accept that ageing is a part of life. Your body and energy levels change. This is all part of ageing. Don't be too critical of yourself. Your body is working hard for you every day, so treat it with compassion.  
  • Stabilise your blood sugar. Eat less (fast) carbohydrates and sugars, and more protein, slow carbohydrates and healthy fats. Full-fat yogurt is an excellent choice!  
  • Limit the number of meals per day to three or four. This will lower blood sugar and prevent blood sugar spikes.   
  • Stop eating two to three hours before bedtime. This will give your body enough time to digest your food.  
  • Do strength training twice a week. Strength training increases muscle mass. This improves, among other things, metabolism, making it easier to lose weight and keep it off.   
  • Incorporate moments for rest and relaxation into your daily routine. Take a walk, read a book, or do something else that helps you unwind. This will make you less stressed and tired, and help with sugar cravings.

What if it isn’t enough?

Sometimes a healthy lifestyle isn't enough. What are your options if you decide to go the medicinal route? And what do you need to know?  

What options are available to you?  

The most commonly prescribed weight loss medications come in two forms, capsules (to be taken daily by mouth) and self-administered injections. Each medicine works in a slightly different way.  

  • They lower blood sugar levels, enhance insulin secretion in response to elevated blood glucose levels, and reduce excessive glucose production. 

  • They work on areas in the brain involved in the control of food intake and energy expenditure. 

  • They slow the movement of food from the stomach into the small intestine, which helps reduce appetite and makes it easier to stick to a diet. 

  • They reduce the absorption of fat, making you take in fewer calories. 

What do you need to know?  

  • Weight loss medicines aren't for everyone. People who are overweight are considered a candidate for these medicines if they have a body mass index (BMI) of 30 kg/m2 or higher, or if they have a BMI between 25 and 30 and an increased risk of type 2 diabetes, cardiovascular disease, osteoarthritis or sleep apnoea.  

  • Remember, healthy lifestyle choices are the foundation of weight loss. Weight loss medications should be a temporary solution. They are meant to be used alongside a healthy, balanced diet and regular exercise. If you continue with unhealthy lifestyle behaviours, you’ll rebound back to your old weight (or even heavier).  

  • Weight loss medications may cause side effects. Common side effects include headache, nausea and gastrointestinal symptoms, such as diarrhoea, constipation and bloating. 

Sources

  • Kapoor E, Collazo-Clavell ML, Faubion SS. (2017). Weight Gain in Women at Midlife: A Concise Review of the Pathophysiology and Strategies for Management. PMID: 28982486.
  • Dupuit M, Maillard F, Pereira B, Marquezi ML, Lancha AH Jr, Boisseau N. (2020). Effect of high intensity interval training on body composition in women before and after menopause: a meta-analysis. PMID: 32613697.
  • Borghouts LB, Keizer HA. (2000). Exercise and insulin sensitivity: a review. PMID: 10683091. 
  • Li L, Li X, Zhou W, Messina JL. (2013). Acute psychological stress results in the rapid development of insulin resistance. PMID: 23444388.
  • McAuley KA, Hopkins CM, Smith KJ, McLay RT, Williams SM, Taylor RW, Mann JI. (2005). Comparison of high-fat and high-protein diets with a high-carbohydrate diet in insulin-resistant obese women. PMID: 15616799.
  • Lovejoy JC. (1998). The influence of sex hormones on obesity across the female life span. PMID: 9929857.
  • Hewagalamulage SD, Lee TK, Clarke IJ, Henry BA. (2016). Stress, cortisol, and obesity: a role for cortisol responsiveness in identifying individuals prone to obesity. PMID: 27345309.
  • Kodoth V, Scaccia S, Aggarwal B. (2022). Adverse Changes in Body Composition During the Menopausal Transition and Relation to Cardiovascular Risk: A Contemporary Review. PMID: 35814604.
  • Stachenfeld, N. S. (2014). Hormonal changes during menopause and the impact on fluid regulation. Reproductive Sciences, 21(5), 555-561. doi: 10.1177/1933719113518992.

FAQ

Tips and advice

Reviewed by
Arco Verhoog, Pharmacist
Registration number:
19065378617
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